![]() ![]() Currently, two synthetic cannabinoids, dronabinol (schedule III) and nabilone (schedule II), are approved by the FDA for clinical use in patients ( 5). Another major cannabinoid, delta-9-tetrahydrocannabinol (THC), was isolated in 1964 in Israel by Raphael Mechoulam, and this subsequently led to the discovery of the cannabinoid receptors (CB) and the endocannabinoid system ( 23). The first cannabinoid, cannabinol, was isolated in 1896 and was further synthesized in 1940. Cannabis and products derived from it have been widely used for recreational and/or medicinal purposes dating back to 4000 B.C. This will help limit the deleterious effects of these substances while promoting their potential beneficial impact on renal function in various types of kidney diseases.Ĭannabis, also known as marijuana, is an umbrella term used for preparations obtained from plants that fall under the genus Cannabis in the plant family cannabaceae ( 60). Given the increasing public health relevance of cannabis exposure, it is clear that more research is necessary to clarify the various physiological and pathophysiological effects of cannabis and related analogs on the kidney. Furthermore, a better understanding of the impact of exocannabinoids and endocannabinoids on the renal system may lead to the development of new drugs to treat kidney disease and its complications. To date, the mechanisms by which the CB 1 or CB 2 receptors are involved in the pathology of these renal conditions remain to be fully described. Experimental studies suggest that stimulation of these receptors using pharmacologic agents or their naturally occurring ligands could have both deleterious and beneficial effects on the kidneys, depending on receptor distribution, type of renal insult, or the timing of the activation during acute or chronic states of kidney injury. ![]() The two different types of receptors (CB 1 and CB 2) that are activated by the pharmacologically active ingredients of cannabis are found in numerous tissues, including the kidneys. Furthermore, regulatory changes are fostering a cultural shift toward increasing liberalization of cannabis use, thereby increasing the likelihood of even larger numbers of individuals being exposed in the future. Consumption of cannabis and various related products (cannabinoids) for both medicinal and recreational use is gaining popularity. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |